Female Patient

HARPOON Beating Heart Mitral Valve Repair System

A new trial of a minimally invasive treatment for severe degenerative mitral regurgitation 

Degenerative mitral regurgitation

What is degenerative mitral regurgitation?

Degenerative mitral regurgitation is a condition in which the valve’s two flap-like leaflets and supporting string-like structures (chords) are too stretchy and may even break.

When the heart contracts, the valve’s leaflets may not close correctly. This causes regurgitation, which occurs when blood leaks backward into the left atrium with each heartbeat.

Symptoms

However, some patients may not experience any symptoms at all.

What is the HARPOON system?

The HARPOON system is an investigational device designed to repair the damaged mitral valve on a beating heart.

How does it work?

1
Echo screening and clinical assessments to determine eligibility
2
HARPOON procedure performed by a heart surgery team in an operating room
3

Post-procedure doctor's visits and additional testing

Post-procedure timeline

You may qualify if you:

Talk to your doctor or the clinical trial coordinator about the full list of eligibility criteria.

You may not qualify if you:

Where can I participate?

Continue the conversation with your cardiologist to determine if the RESTORE trial is right for you or find a heart surgeon participating in the trial below.

Find a RESTORE trial site near you

Los Angeles


Keck Medicine of USC

Surgeon

Dr. Mark Cunningham

Coordinator

Stephanie Mullin
Site Number: 323-430-3960


Ronald Reagan UCLA Medical Center

Surgeon

Dr. Richard Shemin

Coordinator

Nancy Satou
Site Number: 310-206-4168
Kimberly Lauang
Site Number: 310-825-0082
 

Palo Alto


Stanford University Medical Center

Surgeon

Dr. John MacArthur

Coordinator

Tiffany Koyano
Site Number: 650-724-6921

San Franscisco


UCSF Medical Center

Surgeon

Dr. Tom Nguyen
Dr. Vaikom Mahadevan

Coordinator

Jason Wu
Site Number: 415-602-5631

Orlando


AdventHealth Orlando

Surgeon

Dr. Kevin Accola

Coordinators

Sandra Houser
Site Number: 407-303-9418

Sarasota


Sarasota Memorial Hospital

Surgeon

Dr. Jonathan Hoffberger

Coordinators

Colleen Lindner
Site Number: 941-917-1669

Atlanta

Piedmont Heart Institute

Surgeon

Dr. Federico Milla

Coordinator

Akimi Rhodes
Site Number: 404-605-2371

Indianapolis


St. Vincent Hospital of Indiana

Surgeon

Dr. David Heimansohn

Coordinator

Cheree Slusher
Site Number: 317-583-7804

Baltimore

University of Maryland Medical Center

Surgeon

Dr. Murtaza Dawood

Coordinator

N/A
Site Number: 410-328-5842

Boston

Massachusetts General Hospital

Surgeon

Dr. Serguei Melnitchouk

Coordinator

Annika Gallandt
Site Number: 617-643-9324

Ann Arbor


University of Michigan Health System

Surgeon

Dr. Matthew Romano

Coordinator

Jessica Oakley
Site Number: 734-232-9051

Rochester

Mayo Clinical

Surgeon

Dr. Arman Arghami
Phone Number: 507-293-6218

Coordinator

Julie Mathews (Admin Asst.)
Site Number: 507-255-4377

Morristown


Morristown Medical Center

Surgeon

Dr. John Brown

Coordinator

Jessica Bukhari
Site Number: 973-971-8597

New York


Weill Cornell

Surgeon

Dr. Stephanie Mick

Coordinator

Nathan Palanparthi
Site Number: 212-746-5594

Durham


Duke University Medical Center

Surgeon

Dr. Jeffrey Gaca

Coordinator

Sarah Casalinova
Site Number: 919-613-5621

Philadelphia


Hospital of the University of Pennsylvania

Surgeon

Dr. William Szeto

Coordinators

Eva Laverty
Site Number: 215-300-7456
Marissa Konig
Site Number: 215-662-8456

Wormleysburg


UPMC/Pinnacle Health Hospitals

Surgeon

Dr. Mubashir Mumtaz

Coordinators

Regina Hollister
Site Number: 717-645-8617

Wynnewood


Lankenau Medical Center

Surgeon

Dr. Basel Ramlawi

Coordinators

Sherry McDermott
Site Number: 484-476-8641

Murray


Intermountain Heart Institute

Surgeon

Dr. John Doty

Coordinator

Erika Hummel
Site Number: 801-507-4731

Caution: Investigational device. Limited by Federal (United States) law to investigational use. The device is not available for marketing or commercial sale in the United States. Edwards Lifesciences is the sponsor of the RESTORE trial. 

Edwards, Edwards Lifesciences, the stylized E logo and HARPOON are trademarks or service marks of Edwards Lifesciences Corporation or its affiliates. All other trademarks are property of their respective owners.

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