Female Patient

HARPOON Beating Heart Mitral Valve Repair System

A new trial of a minimally invasive treatment for severe degenerative mitral regurgitation

Degenerative mitral regurgitation

What is degenerative mitral regurgitation?

Degenerative mitral regurgitation is a condition in which the valve’s two flap-like leaflets and supporting string-like structures (chords) are too stretchy and may even break.

When the heart contracts, the valve’s leaflets may not close correctly. This causes regurgitation, which occurs when blood leaks backward into the left atrium with each heartbeat.

Symptoms

However, some patients may not experience any symptoms at all.

What is the HARPOON system?

The HARPOON system is an investigational device designed to repair the damaged mitral valve on a beating heart.

How does it work?

1
Echo screening and clinical assessments to determine eligibility
2
HARPOON procedure performed by a heart surgery team in an operating room
3

Post-procedure doctor's visits and additional testing

Post-procedure timeline

You may qualify if you:

Talk to your doctor or the clinical trial coordinator about the full list of eligibility criteria.

You may not qualify if you:

Where can I participate?

Continue the conversation with your cardiologist to determine if the RESTORE trial is right for you or find a heart surgeon participating in the trial below.

Find a RESTORE trial site near you

Los Angeles

Keck Medicine of USC

Surgeon

Dr. Mark Cunningham

Coordinator

Stephanie Mullin
Site Number: 323-430-3960

Palo Alto

Standford University Medical Center

Surgeon

Dr. John MacArthur

Coordinator

Tiffany Koyano
Site Number: 650-724-6921

Atlanta

Piedmont Heart Institute

Surgeon

Dr. Federico Milla

Coordinator

Akimi Rhodes
Site Number: 404-605-2371

Indianapolis


St. Vincent Hospital of Indiana

Surgeon

Dr. David Heimansohn

Coordinator

Patrice Powell
Site Number: 317-583-6313

Baltimore

University of Maryland Medical Center

Surgeon

Dr. Murtaza Dawood

Coordinator

N/A
Site Number: 410-328-5842

Boston

Massachusetts General Hospital

Surgeon

Dr. Serguei Melnitchouk

Coordinator

Annika Gallandt
Site Number: 617-643-9324

Ann Arbor

University of Michigan Health System

Surgeon

Dr. Matthew Romano

Coordinator

Nicole Shuler
Site Number: 734-232-4297

Rochester

Mayo Clinical

Surgeon

Dr. Arman Arghami
Phone Number: 507-293-6218

Coordinator

Julie Mathews (Admin Asst.)
Site Number: 507-255-4377

St. Louis

Barnes Jewish / Washington University

Surgeon

Dr. Spencer Melby

Coordinator

Kelly Koogler
Site Number: 314-362-3043

Philadelphia

Hospital of the University of Pennsylvania

Surgeon

Dr. William Szeto

Coordinators

Eva Laverty
Site Number: 215-300-7456
Marissa Konig
Site Number: 215-662-8456

Wormleysburg

UPMC/Pinnacle Health Hospitals

Surgeon

Dr. Mubashir Mumtaz

Coordinators

Regina Hollister
Site Number: 717-645-8617

Caution: Investigational device. Limited by Federal (United States) law to investigational use. The device is not available for marketing or commercial sale in the United States. Edwards Lifesciences is the sponsor of the RESTORE trial. 

Edwards, Edwards Lifesciences, the stylized E logo and HARPOON are trademarks or service marks of Edwards Lifesciences Corporation or its affiliates. All other trademarks are property of their respective owners.

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