Female Patient

HARPOON Beating Heart Mitral Valve Repair System

A new trial of a minimally invasive treatment for severe degenerative mitral regurgitation

Degenerative mitral regurgitation

What is degenerative mitral regurgitation?

Degenerative mitral regurgitation is a condition in which the valve’s two flap-like leaflets and supporting string-like structures (chords) are too stretchy and may even break.

When the heart contracts, the valve’s leaflets may not close correctly. This causes regurgitation, which occurs when blood leaks backward into the left atrium with each heartbeat.

Symptoms

However, some patients may not experience any symptoms at all.

What is the HARPOON system?

The HARPOON system is an investigational device designed to repair the damaged mitral valve on a beating heart.

How does it work?

1
Echo screening and clinical assessments to determine eligibility
2
HARPOON procedure performed by a heart surgery team in an operating room
3

Post-procedure doctor's visits and additional testing

Post-procedure timeline

You may qualify if you:

Talk to your doctor or the clinical trial coordinator about the full list of eligibility criteria.

You may not qualify if you:

Where can I participate?

Continue the conversation with your cardiologist to determine if the RESTORE trial is right for you or find a heart surgeon participating in the trial below.

Find a RESTORE trial site near you

Los Angeles


Keck Medicine of USC

Surgeon

Dr. Mark Cunningham

Coordinator

Stephanie Mullin
Site Number: 323-430-3960


Ronald Reagan UCLA Medical Center

Surgeon

Dr. Richard Shemin

Coordinator

Nancy Satou
Site Number: 310-206-4168
Kimberly Lauang
Site Number: 310-825-0082
 

Newport Beach


Hoag Memorial Hospital Presbyterian

Surgeon

Dr. Anthony Caffarelli

Coordinator

Gene Graham
Site Number: 949-764-4511

Palo Alto


Stanford University Medical Center

Surgeon

Dr. John MacArthur

Coordinator

Tiffany Koyano
Site Number: 650-724-6921
 

San Franscisco


UCSF Medical Center

Surgeon

Dr. Tom Nguyen
Dr. Vaikom Mahadevan

Coordinator

Jordyn Pinochi
Site Number: 628-206-4624

London

London Health Sciences Centre, University Hospital

Surgeon
Dr. Michael Chu
Site Number: 519-685-8500 ext. 35031

Hartford

Hartford Hospital

Surgeon
Dr. Sabet Hashim
Coordinators
Jill Cloutier
Site Number: 860-972-2579

Orlando


AdventHealth Orlando

Surgeon

Dr. Kevin Accola

Coordinators

Sandra Houser
Site Number: 407-303-9418

Sarasota


Sarasota Memorial Hospital

Surgeon

Dr. Jonathan Hoffberger

Coordinators

Colleen Lindner
Site Number: 941-917-1669

Atlanta

Piedmont Heart Institute

Surgeon

Dr. Federico Milla

Coordinator

Akimi Rhodes
Site Number: 404-605-2371

Indianapolis

St. Vincent Hospital of Indiana

Surgeon
Dr. David Heimansohn
Coordinator
Hannah Willard
Site Number: 317-583-7804

Baltimore

Johns Hopkins

Surgeon
Dr. Ahmet Kilic
Coordinator
Lisa Fornaresio
Site Number: 410.955.3597

Baltimore

University of Maryland Medical Center

Surgeon
Dr. Bradley Taylor
Coordinator
N/A
Site Number: 410-328-5842

Boston

Massachusetts General Hospital

Surgeon
Dr. Serguei Melnitchouk
Coordinator
Tracy Winship
Site Number: 617-724-7629

Ann Arbor


University of Michigan Health System

Surgeon

Dr. Matthew Romano

Coordinator

Nicole White
Site Number: 734-232-9051

Rochester

Mayo Clinical

Surgeon

Dr. Arman Arghami
Phone Number: 507-293-6218

Coordinator

Julie Mathews (Admin Asst.)
Site Number: 507-255-4377

St. Louis

Barnes Jewish Hospital

Surgeon
Dr. Spencer Melby
Coordinator
JKyle Stumbaugh
Site Number: 314-747-0707

Morristown


Morristown Medical Center

Surgeon

Dr. John Brown

Coordinator

Jessica Bukhari
Site Number: 973-971-8597

New Brunswick


Rutgers Robert Wood Johnson Medical School

Coordinator

Meghan Smith
Site Number: 732-235-9027

New York


Weill Cornell

Surgeon

Dr. Stephanie Mick

Coordinator

Marshagay Rodriques
Site Number: 212-746-5594

Durham


Duke University Medical Center

Surgeon

Dr. Jeffrey Gaca

Coordinator

Sarah Casalinova
Site Number: 919-613-5621

Portland


OHSU Knight Cardiovascular Institute

Surgeon

Ellie Rogge
Site Number: 503-494-6072

Philadelphia

Hospital of the University of Pennsylvania

Surgeon
Dr. William Szeto
Coordinators
Marissa Konig
Site Number: 215-662-8456

Wormleysburg

UPMC/Pinnacle Health Hospitals

Surgeon
Dr. Mubashir Mumtaz
Coordinators
Matthew Rutt
Site Number: 717-645-8617
 

Pittsburgh

Allegheny General Hospital

Surgeon
Dr. Walter McGregor
Coordinators
Veronica Galuska
Site Number: 412-359-3802

Nashville


Centennial Medical Center

Surgeon

Dr. Sreekumar Subramanian
Site Number: 615-329-6856

Murray


Intermountain Heart Institute

Surgeon

Dr. John Doty

Coordinator

Erika Hummel
Site Number: 801-507-4731

Falls Church

Inova Fairfax Hospital

Surgeon
Dr. Eric sarin
Coordinator
Ian Leung
Site Number: 703-776-4096

Seattle

Swedish Medical Center

Surgeon
Dr. Eric Lehr
Coordinator
Janet Zaltsman
Site Number: 206-215-2455

Caution: Investigational device. Limited by Federal (United States) law to investigational use. The device is not available for marketing or commercial sale in the United States. Edwards Lifesciences is the sponsor of the RESTORE trial. 

Edwards, Edwards Lifesciences, the stylized E logo and HARPOON are trademarks or service marks of Edwards Lifesciences Corporation or its affiliates. All other trademarks are property of their respective owners.

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